1 Discuss the differences between narcotics and opiates, examining their specific meanings and how the terms are often used interchangeably. Explore the characteristics and origins of opium, its role as an analgesic and euphoriant. 2. Compare and contrast the mechanisms of action and clinical efficacy of Tricyclic Antidepressants (TCAs), Monoamine Oxidase Inhibitors (MAOIs), Serotonin-Selective Reuptake Inhibitors (SSRIs), and Serotonin/Norepinephrine-Selective Reuptake Inhibitors (SNRIs) as different classes of antidepressant medications