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1. Dukes' C Colorectal Cancer and Diet Treatment. Colorectal cancer is a common cause of death. In the advanced stage of disease, when the disease

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1. Dukes' C Colorectal Cancer and Diet Treatment. Colorectal cancer is a common cause of death. In the advanced stage of disease, when the disease is rst diagnosed in many patients, surgery is the only treatment. Cytotoxic drugs, when given as an adjunct to surgery, do not prevent relapse and do not increase the survival in patients with advanced disease. Interest has been shown, at least by patients, in a nutritional approach to treatment, where diet plays a critical role in the disease management program. In a controlled clinical trial, McIllmurray and Turkie (1987) evaluated the diet treatment in patients with Dukes' C colorectal cancer, because the residual tumour mass is small after operation, the relapse rate is high, and no other effective treatment is available. The diet treatment consisted of linolenic acid, an oil extract of the seed from the evening primrose plant Onagmcece Oenothem biennis and vitamin E. The data for the treatment and control patients are given below: Treatment Survival time (months) Linoleic acid 1+, 5+, 6, 6, 9+, 10, 10, 10+, 12, 12, 12, 12, 12+, 13+, 15+, (121 = 25) 16+, 20+, 24, 24+, 27+, 32, 34+, 36+, 36+, 44+ Control 3+, 6, 6, 6, 6, 8, 8, 12, 12, 12+, 15+, 16+, 18+, 18+, 20, 22+, [122 = 24) 24, 28+, 28+, 28, 30, 30+, 33+, 42 Fit the data with Weibull distribution, taking the treatment / control (1/0) as a covariate. Place noninformative priors on all parameters. Consult the le Leukemia.odc from the repositorv. Is the linoleic acid treatment benecial? Comment

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