1. For an enzyme-catalyzed reaction obeying Michaelis-Menten kinetics, Vmar = 5.0 x 10-9 M/s and Km = 1.0 x 10-3 M. Calculate the rate of this enzymatic reaction when [S] = 2.0 x 10-3 M. 2. For an enzyme obeying Michaelis-Menten kinetics, at what concentration of S (substrate, expressed as a multiples of Km) will the initial velocity be equal to 75% of Vmax