1. Question 1

2. As cells grow and regenerate, what mechanism does the body use to

3. get rid of the continuously dying cells? And what kind of cells can't be

4. replaced once dead?

5. Question 2

6. I cannot find out why some of the autosomal dominant diseases have a

7. male or female preponderance, e.g. I have never seen a female Marfans. I

8. was attributing it to imprinting but on reading about imprinting in detail

9. it cannot be the case.

10. Question 3

11. We have been told that some tumours in the colon are associated with

12. microsatellite instability. What does this mean?

13. Question 4

14. I understand that microarrays are being used to define the molecular

15. abnormality and the prognosis in some patients with leukaemia. What

16. are microarrays?

17. Question 5

18. Why do mitochondrial diseases cause a myopathy?

19. Question 6

20. Why do successive generations of patients with some genetic disorders

21. present earlier and with progressively worse symptoms.

22. 5

23. 2 Molecular cell biology and

24. genetic disorders2 Molecular cell biology and genetic disorders

25. 6

26. Question 7

27. Does a normal serum uric acid level exclude the diagnosis of

28. Lesch-Nyhan syndrome?

29. Question 8

30. How is retinoblastoma an autosomal dominant disease if the mutation of

31. both RB genes is required to express the disease?