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1) The antidepressant fluoxetine sold under the brand name Prozac, can be prepared by a substitution reaction of an alkyl chloride with phenol using a
- 1) The antidepressant fluoxetine sold under the brand name Prozac, can be prepared by a substitution reaction of an alkyl chloride with phenol using a weak base to generate the phenoxide ion. A) Identify the nucleophile in this reaction. B) Identify the electrophile in this reaction. C) If the rate of reaction depends on the concentration of both alkyl chloride and phenol, is this an SN1 or SN2 reaction? D) Identify the chiral center in the alkyl chloride starting material. E) Given that amines such as Prozac from salt with carboxylic acids, draw a carboxylic acid that might allow you to resolve the racemate of Prozac.
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