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1 . The solubility of a monoclonal antibody ( MW 1 5 5 , 0 0 0 kg kg - mole - 1 ) in

1. The solubility of a monoclonal antibody (MW 155,000 kg kg-mole-1) in 1.5 kg-moles m-3 ammonium sulfate solutions is 0.1 g L-1. Predict its solubility in an ammonium sulfate-free buffer if the salting out constant is 5.6 m3 kg-mole-1. If we increase the ammonium sulfate concentration of 100 mL of a 0.5 g L-1 monoclonal antibody solution from zero to
1.75 kg-moles m-3, what fraction of the monoclonal antibody will be precipitated?

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