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1 ) There are two possible sites for insertion of the Mg atom into the C X bonds of 1 - bromo - 4 -

1) There are two possible sites for insertion of the Mg atom into the CX bonds of 1-bromo-4-
chlorobenzene, and thus two different Grignard reagents that can be formed.
a) Draw each of the possible Grignard reagents and the product they would generate upon reaction
with DMF (assume acidic workup) as detailed in Scheme 21.2.(2 pts)
b) Predict the m/z value(s) for the molecular ion(s) of each of the possible products from the
reaction of the Grignard reagents considered in question 1 with DMF.(2 pts)
2) Explain why all glassware must be dry and the solvent anhydrous during formation and
reaction of a Grignard reaction. Explain whether acetone would be a viable solvent for
generation of a Grignard reagent. Include one or more balanced chemical equations in your
answer. There are two possible sites for insertion of the Mg atom into the C-x bonds of 1-bromo-4-
chlorobenzene, and thus two different Grignard reagents that can be formed.
a) Draw each of the possible Grignard reagents and the product they would generate upon reaction
with DMF (assume acidic workup) as detailed in Scheme 21.2.(2 pts)
b) Predict the mz value(s) for the molecular ion(s) of each of the possible products from the
reaction of the Grignard reagents considered in question 1 with DMF.(2 pts)
Explain why all glassware must be dry and the solvent anhydrous during formation and
reaction of a Grignard reaction. Explain whether acetone would be a viable solvent for
generation of a Grignard reagent. Include one or more balanced chemical equations in your
answer. (4 pts)
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