1) Valproic acid (VPA) is a medication used to treat epilepsy. Assume VPA exhibits "one compartment" pharmacokinetics. In an adult patient, the assumed values of VPA clearance and volume of distribution are 0.58 L/hr and 11.0L, respectively. How much drug is in the body (in mg) when the VPA plasma concentration measures 58 mg/L?

2) When 70 mg of a drug is administered as an IV bolus dose, the plasma concentrations (mg/L) observed over time can be described by the following equation:

C = 7.14e -0.015t

note: the units on concentration (C) are ug/mL

Calculate the elimination half-life (in hours)