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10. Binding of druglike molecules to proteins is often potentiated by intermolecular forces between the various structural components of the molecule and the amino acids

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10. Binding of druglike molecules to proteins is often potentiated by intermolecular forces between the various structural components of the molecule and the amino acids within the protein. For this question, we are going to keep our focus on the hormone analogue introduced on the previous page, with the same color coding (dark green = carbon, red = oxygen, blue = nitrogen, and lime green = chlorine). Each of the crystal structures shown below highlights a key interaction indicated by a bright pink dotted line) between the amino acids of the protein and the hormone analogue. In each case, first give the three-letter code for any amino acid(s) featured in the crystal structure, then name the intermolecular force involved in the interaction. Valid choices are ionic interaction, hydrogen bonding, and van der Waals (nonpolar) interaction. Be specific about which portion of the amino acid(s) is interacting with which portion of the molecule. (If two lines are shown for a given interaction, it is because resonance makes the atoms involved practically indistinguishable.) a) b) c) a d)

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