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102. Type of ring structures present in the structure of diazepam? a) Quiniclidine b) Quinoline c) Diazepine d) All of the above 103. Due to

102. Type of ring structures present in the structure of diazepam?
a) Quiniclidine
b) Quinoline
c) Diazepine
d) All of the above


103. Due to Potentiation of GABA receptors by Thiamylal?
a) Increase in opening duration of calcium channels
b) Increase in opening duration of the Chloride channels
c) Increase in opening duration of the Sodium channels
d) Decrease in opening duration of the calcium channels


104. Therapeutic use of drug Thiamylal is/are?
a) Induction of surgical anesthetics
b) Inducing drowsiness
c) Reducing anxiety

d) All of the above


105. Which amongst the following are the correct statements with respect to the SAR of drug
Thiamylal
I. Tri-keto form is most stable in aqueous solution.
II. 4,6-dialcoholic tautomeric forms are least stable in aqueous solution.
III. 5,5-disubstituted barbituric acid is the prime requirement for the barbituares to be sedative
hypnotics.
IV. Esterification of either of the 1,3-diazine nitrogens decreases hypnotic activity.
a) I, III, IV
b) II, IV
c) I, II, III
d) I, II, III, IV


106. The starting chemicals required for the synthesis of drug Thiamylal?
a) Malonic ester
b) Barbital
c) Both a) and b)
d) None of the above


107. Correct sequence for the True/False for the physiochemical properties of the drug Thiamylal
is?
I. Molecular weight is 254.35 g/mol
II.It is present in liquid crystalline form
III. Melting point is 132.5oC
IV. No chiral carbons are present in the structure of barbital.
a) TFTF
b) TFFF
c) FFFT
d)FTTF

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