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11. Use the Needleman-Wunsch software program to perform two pairwise sequence alignments. For one alignment, use the BLOSUM30 substitution matrix, and for the other, use
11. Use the Needleman-Wunsch software program to perform two pairwise sequence alignments. For one alignment, use the BLOSUM30 substitution matrix, and for the other, use BLOSUM90 substitution matrix. Report the identity and similarity score for each alignment. Explain why these values differ depending on the substitution matrix. Use human p53 and Xen- opus laevis p53 as inputs for your pairwise se- quence alignments. Here are parameters to use for the alignments when running the software program: Matrix: Gap Open Penalty: 10; Gap Extend Penalty: 0.5; End Gap Penalty: False; End Gap Open Penalty: 10; End Gap Extend Penalty: 0.5 11. Use the Needleman-Wunsch software program to perform two pairwise sequence alignments. For one alignment, use the BLOSUM30 substitution matrix, and for the other, use BLOSUM90 substitution matrix. Report the identity and similarity score for each alignment. Explain why these values differ depending on the substitution matrix. Use human p53 and Xen- opus laevis p53 as inputs for your pairwise se- quence alignments. Here are parameters to use for the alignments when running the software program: Matrix: Gap Open Penalty: 10; Gap Extend Penalty: 0.5; End Gap Penalty: False; End Gap Open Penalty: 10; End Gap Extend Penalty: 0.5
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