1a) Convert Figure 2a of the posted paper (by Usim, 2004) into a Forrester Diagram (see also posted chapter on Forrester Diagrams).

Submit the following items (you can combine your items b-e):

1. Submit your Matlab code
2. Include your Forrester Diagram (integrated in doc-file or pdf)
3. Plot the outcome of your simulation for Cg, Cl, Cc and Cm (doc/image or pdf)
4. Discuss the behavior of these parameters with respect to the model structure and parameters (doc/pdf, approximately 5 sentences).

Change one parameter to improve clearance by the liver compartment (simulating a drug). If you do, how does this improve the overall ethanol clearance? Explain what you did and provide a simulation.

Please help, thank you!

1a) Convert Figure 2a of the posted paper (by Usim, 2004) into a Forrester Diagram (see also posted chapter on Forrester Diagrams). 1b) Use code from Berkeley Madonna listed below as a starting point to develop your own Matlab implementation. Use ode45 (RK4 solver). Of note, the code is simplified and is tuned towards a specific ethanol dose (5g) but should deliver a qualitative similar behavior to what is published in the paper. Submit the following items (you can combine your items b-e): a) Submit your Matlab code b) Include your Forrester Diagram (integrated in doc-file or pdf) c) Plot the outcome of your simulation for Cg,Cl,Cc and Cm (doc/image or pdf) d) Discuss the behavior of these parameters with respect to the model structure and parameters (doc/pdf, approximately 5 sentences). e) Change one parameter to improve clearance by the liver compartment (simulating a drug). If you do, how does this improve the overall ethanol clearance? Explain what you did and provide a simulation