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2 6 . 6 Consider the drug patch shown in Problem 2 6 . 4 . The patch consists of a pure solid drug source

26.6 Consider the drug patch shown in Problem 26.4. The
patch consists of a pure solid drug source mounted on top of a
water-swollen polymer, which acts as a controlled diffusion
barrier. The square patch is 4.0 cm 4.0 cm. The bottom
surface of the diffusion barrier is in direct contact with the skin.
The desired amount of cumulative drug release is 0.02\mu mole
after 10 hours. Independent experiments have shown that the
drug is immediately taken up into the body after exiting the
patch. The maximum solubility of the drug in the water-swollen
polymer is 0.50\mu mole/cm3
, which is dilute. The effective
diffusion coefficient DAe of the drug in the water-swollen
polymer is 208107 cm2/s. What is the required thickness
(L) of the diffusion barrier component of the drug patch needed
to achieve the desired drug release profile?

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