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2 6 . 6 Consider the drug patch shown in Problem 2 6 . 4 . The patch consists of a pure solid drug source
Consider the drug patch shown in Problem The patch consists of a pure solid drug source mounted on top of a waterswollen polymer, which acts as a controlled diffusion barrier. The square patch is cm cm The bottom surface of the diffusion barrier is in direct contact with the skin. The desired amount of cumulative drug release is mu mole after hours. Independent experiments have shown that the drug is immediately taken up into the body after exiting the patch. The maximum solubility of the drug in the waterswollen polymer is mu molecm which is dilute. The effective diffusion coefficient DAe of the drug in the waterswollen polymer is cms What is the required thickness L of the diffusion barrier component of the drug patch needed to achieve the desired drug release profile?
Consider the drug patch shown in Problem The
patch consists of a pure solid drug source mounted on top of a
waterswollen polymer, which acts as a controlled diffusion
barrier. The square patch is cm cm The bottom
surface of the diffusion barrier is in direct contact with the skin.
The desired amount of cumulative drug release is mu mole
after hours. Independent experiments have shown that the
drug is immediately taken up into the body after exiting the
patch. The maximum solubility of the drug in the waterswollen
polymer is mu molecm
which is dilute. The effective
diffusion coefficient DAe of the drug in the waterswollen
polymer is cms What is the required thickness
L of the diffusion barrier component of the drug patch needed
to achieve the desired drug release profile?
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