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2. A 50Kg woman was given a single IV dose of an antibacterial drug at a dose level of 6mg/Kg. blood samples were taken at
2. A 50Kg woman was given a single IV dose of an antibacterial drug at a dose level of 6mg/Kg. blood samples were taken at various time intervals. The concentration of the drug (Cp) was determined in the plasma fraction of each blood sample and the following data were obtained: a. What are the values for Vd,k, and t1/2 ? b. This antibacterial agent is not effective at a plasma concentration of less than 2 ug/ml. what is the duration of activity for this drug? c. How long would it take for 99.9% of this drug to be elimination? If the dose of the antibiotic were doubled exactly. What would be the increase in duration of activity? (6Marks)
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