Answered step by step
Verified Expert Solution
Question
1 Approved Answer
(2S,3S)-2,3-dicarboxyaziridine is a potent competitive inhibitor (Ki = 80 nM) of fumarase, an enzyme that catalyzes the hydration of fumaric acid to (S)-malic acid. Rationalize
(2S,3S)-2,3-dicarboxyaziridine is a potent competitive inhibitor (Ki = 80 nM) of fumarase, an enzyme that catalyzes the hydration of fumaric acid to (S)-malic acid. Rationalize how (2S,3S)-2,3-dicarboxyaziridine might act as a competitive inhibitor of fumarase. Would you expect the enantiomer of the inhibitor to have a higher or lower Ki value? Explain.
Step by Step Solution
There are 3 Steps involved in it
Step: 1
Get Instant Access to Expert-Tailored Solutions
See step-by-step solutions with expert insights and AI powered tools for academic success
Step: 2
Step: 3
Ace Your Homework with AI
Get the answers you need in no time with our AI-driven, step-by-step assistance
Get Started