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4 . Aspirin is a neutral molecule and a weak acid with a pKa of 3 . 4 . If it is given orally it

4. Aspirin is a neutral molecule and a weak acid with a pKa of 3.4. If it is given orally it is absorbed (as a neutral molecule) into the blood through the cells lining the stomach and the small intestine. The pH of gastric juice is about 1.5 and the pH of the contents of the small intestine is about 6.0. Is more aspirin absorbed into the bloodstream from the stomach or from the small intestine. Justify your answer by calculating the ratio of neutral aspirin to dissociated aspirin at the two pH values.

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