4.12 A blood sample taken from a 113-lb. pa- tient 6 hours after heparin therapy is ini- tiated shows a PTT of 24 seconds. Calcu- late (a) the bolus dose and (b) the infusion rate, in mL/hr, according to the high-dose heparin protocol (Fig. 10.1). Answers a- 3595 units. B- 11.3 ml/hr

Please follow this figure :

or For a PTT Value of 50 to 70 seconds (LOW-DOSE HEPARIN PROTOCOL) No Bolus Dose Start heparin drip at a rate of Bolus with 70 units of heparin per kg (limit 10,000 units) 15 units per kg per hr Bolus with units of heparin units per kg per hr PTT Value Heparin Dose Adjustments 120 seconds Hold heparin infusion for 1 hour, when restarted, decrease heparin infusion rate by 3 units per kg per hour For a PTT Value of 70 to 99 seconds (HIGH-DOSE HEPARIN PROTOCOL) No Bolus Dose Start heparin drip at a rate of Bolus with 70 units of heparin per kg (limit 10,000 units) 18 units per kg per hr Bolus with units of heparin units per kg per hr PTT Value Heparin Dose Adjustments 120 seconds Hold heparin infusion for 1 hour, when restarted, decrease heparin infusion rate by 2 units per kg per hour DATE TIME or M.D. or For a PTT Value of 50 to 70 seconds (LOW-DOSE HEPARIN PROTOCOL) No Bolus Dose Start heparin drip at a rate of Bolus with 70 units of heparin per kg (limit 10,000 units) 15 units per kg per hr Bolus with units of heparin units per kg per hr PTT Value Heparin Dose Adjustments 120 seconds Hold heparin infusion for 1 hour, when restarted, decrease heparin infusion rate by 3 units per kg per hour For a PTT Value of 70 to 99 seconds (HIGH-DOSE HEPARIN PROTOCOL) No Bolus Dose Start heparin drip at a rate of Bolus with 70 units of heparin per kg (limit 10,000 units) 18 units per kg per hr Bolus with units of heparin units per kg per hr PTT Value Heparin Dose Adjustments 120 seconds Hold heparin infusion for 1 hour, when restarted, decrease heparin infusion rate by 2 units per kg per hour DATE TIME or M.D