Question
For a high extraction drug (e.g. metoprolol) administered IV to an elderly subject with reduced hepatic blood flow, which of the following is/are INCORRECT: Clearance
For a high extraction drug (e.g. metoprolol) administered IV to an elderly subject with reduced hepatic blood flow, which of the following is/are INCORRECT:
Clearance of metoprolol stays the same because high extraction drugs behave like a low extraction drug when administered IV
Clearance of metoprolol stays the same because high extraction drugs behave like a high extraction drug when administered IV
Clearance of metoprolol is increased because the free fraction is increased
Clearance of metoprolol is increased because the free fraction is decreased
Clearance of metoprolol is decreased because the intrinsic clearance is decreased
Clearance of metoprolol is decreased because the intrinsic clearance is increased
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The detailed answer for the above question is provided below Answer The first answer is INCORRECT Clearance of metoprolol does not stay the same becau...
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Income Tax Fundamentals 2015
Authors: Gerald E. Whittenburg, Martha Altus Buller, Steven Gill
33rd Edition
9781305177772, 128543952X, 1305177770, 978-1285439525
