Question
5 The reaction of the amine with the ketone, as shown below, was carried out under acidic conditions to give a cyclic product. 1. present
5
The reaction of the amine with the ketone, as shown below, was carried out under acidic conditions to give a cyclic product.
1. present a complete scheme of unit reactions that take place from the stage of mixing the substrate and reactant to the formation of the product
2. for a number of substrates where X = OMe, NMe2, OH, H, F, Cl, CN, it was determined that the reaction involving the aromatic ring slows down. What will be the nature of the transition state in this reaction? Draw a potential plot of log(kx/kh) versus the nature of the substituent
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