90. Ethanol is used in methanol poisoning because it
(a) Antagonises the actions of methanol
(b) Stimulates the metabolism of methanol and reduces its blood level
(c) Inhibits the metabolism of methanol and generation of toxic metabolite
(d) Replenishes the folate stores depleted by methanol

91. The mechanism of action of barbiturates differs from that of benzodiazepines in that they
(a) Do not affect the GABA–benzodiazepine receptor–chloride channel complex
(b) Act as inverse agonists at the benzodiaze-pine receptor
(c) Increase the frequency of chloride channelopening without affecting its life time
(d) Have both GABA–facilitatory as well asGABA–mimetic actions

92. Which one of the following processes plays the major role in terminating the action of
phenobarbitone
(a) Billary excretion
(b) Renal excretion
(c) Hepatic metabolism
(d) Redistribution

93.Currently barbiturates are primarily used as
(a) Hypnotic
(b) Sedative
(c) Antiepileptic
(d) Preanaesthetic medicant

94. Binding of alprazolam with acetylcholine muscarinic receptors results in?
a) Agonizing effect on muscarinic receptors
b) Antagonizing effect on muscarinic receptors
c) Do not produce any significant effect
d) Do not bind with muscarinic receptor

95. Therapeutic use of drug Alprazolam is/are?
a) Treatment of Acute alcohol withdrawal
b) Treatment of seizures
c) Treatment of anxiety
d) All of the above

96. Which amongst the following are the correct statements with respect to the SAR of drug
Alprazolam?
I. Ring A should include an aromatic or heteroaromatic ring for binding with 5-phenyl-1,4-
benzodiazepin-2-one derivatives.
II. An electronegative group at 7-position of the ring A increases the functional anxiolytic
activity.
III. Substitutions at 6, 8 or 9 position with electronegative group on ring A will decrease the
functional anxiolytic activity.
IV. When Heterocycles used as ring A, drug shows poor pharmacological activity.
a) I, IV
b) I, II, IV
c) I, II, III, IV
d) II, III, IV