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A 20 mg dose (IV bolus) of a new medication, LIU000, is administered to a human subject, and plasma and urine samples are collected for
A 20 mg dose (IV bolus) of a new medication, LIU000, is administered to a human subject, and plasma and urine samples are collected for 48 hours post-dose. Your data analysis finds that the elimination rate constant for LIU000 is 0.079 h-1 and the volume of distribution is 58 L. LIU000 is 75% bound to plasma proteins. The cumulative amount of Drug A excreted into the urine (based on a 48 hr total urine collection) was 17 mg. The estimated GFR in this subject was 100 ml/min. What is the renal clearance of LIU000? A 20 mg dose (IV bolus) of a new medication, LIU000, is administered to a human subject, and plasma and urine samples are collected for 48 hours post-dose. Your data analysis finds that the elimination rate constant for LIU000 is 0.079 h-1 and the volume of distribution is 58 L. LIU000 is 75% bound to plasma proteins. The cumulative amount of Drug A excreted into the urine (based on a 48 hr total urine collection) was 17 mg. The estimated GFR in this subject was 100 ml/min. What is the renal clearance of LIU000
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