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A 20m3 working volume of bioreactor is used for producing penicillin. The yield of biomass from substrate is 0.06g.g1;YPx is 7.7g.g-1. The maintenance coefficient is
A 20m3 working volume of bioreactor is used for producing penicillin. The yield of biomass from substrate is 0.06g.g1;YPx is 7.7g.g-1. The maintenance coefficient is 2.2g.g1.h1; the specific rate of Given data: Dtank=2.4m Impeller speed =90rpm Number of blades =8; flat, turbine types of blade Broth viscosity =1mPa.s=1cP =1.2103kg/m3 Aeration rate =1vvm Ratio of gassed to ungassed power Pg/P=0.4 Driving force for OTR =6103kg/m3 Specific O2 uptake =0.65mmolO2/kg cell Specific sugar consumption rate of cells =1kg/kg cell.h max=0.5h1 Calculations to do: 1. Draw the batch reactor systems according to height/weight and where impellers located. Also, show required bioreactor components for the antibiotic production. 2. What would be the sugar concentration (So) you choose if oxygen transfer rate is not the limiting reactant? 3. Define kLa. 4. Determine batch reaction time for producing 100kg antibotic and define the number of batch per year. (Assume down time =30h ) 5. How much does it cost to mix such a reactor per year
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