A clinical trial was conducted to test the effectiveness of a drug for treating insomnia in older subjects. Before treatment, 16 subjects had a mean wake time of 103.0 min. After treatment, the 16 subjects had a mean wake time of 94.2 min and a standard deviation of 21.9 min. Assume that the 16 sample values appear to be from a normally distributed population and construct a 99% confidence interval estimate of the mean wake time for a population with drug treatments. What does the result suggest about the mean wake time of 103.0 min before the treatment? Does the drug appear to be effective? 78.1 min