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A homopolymer of histidine (polyhistidine) adopts an alpha-helix structure at pH 9 but is unfolded at a pH of 4. Explain why using chemical details.

  1. A homopolymer of histidine (polyhistidine) adopts an alpha-helix structure at pH 9 but is unfolded at a pH of 4. Explain why using chemical details.
  2. Compare and contrast the entropy changes of the dissolution of the following two amino acids isoleucine and glutamate (in water).

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