A major threat to the commercial success of small biotechnology companies, identified in a Top Five Consultants' Report, is that of technology consolidation. The report warns that companies relying on a single technological expertise will have grave difficulty in continuing to attract pharmaceutical partner companies, from which they can extract high profit margins. However, the Molecular Allies division has successfully expanded its technological expertise in informatics to a broader range of technological capabilities through its virtual network. The future of the division appears bright if it can build on its current technological capabilities, manage its network, and expand its technological base to include a genomic capability.

Question 41 How can cranial arteritis be diagnosed in the absence of any physical symptom or feature of the disease other than headache?

42 Do pulmonary manifestations in Behet's syndrome present with pulmonary infiltrates in the upper zone of

lung?

43 1. Is Behet's disease accompanied by an elevated erythrocyte sedimentation rate (ESR)? If so, how often? 2. Can Behet's disease be diagnosed in a young adult with an ischaemic stroke and a history of almost weekly mouth ulcers that heal quickly, but with no other symptoms of Behet's disease?

44 Mouth ulcers are too common to be a cardinal feature in the diagnosis of Behet's disease. Are there any distinguishing features other than mouth ulcers that would confirm diagnosis?

45 Please explain how to diagnose familial Mediterranean fever. Is a diagnosis of exclusion still used or are there now more up-to-date tools for the diagnosis?

46 Is a leucocytoclastic reaction in a tissue biopsy specific for Henoch-Schnlein purpura or is it also associated with other problems?

47 What are the anatomical, histological and radiological differences between: 1. physis 2. metaphysis 3. epiphyseal disc 4. epiphyseal line?

48 Why does the serum alkaline phosphatase increase in bone disorders and in some other disorders?

49 What is the normal amount of calcium excreted in the urine in a 24-hour period?

50 Does hydrochlorothiazide have a prophylactic effect against osteoporosis?