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A PRO assessment was performed on the four identified risks. For each of the risks the estimated cost of mitigating the risk (investment) was determined;

A PRO assessment was performed on the four identified risks. For each of the risks the estimated cost of mitigating the risk (investment) was determined; the enterprise net present value (NPV) protected was calculated given the investment was made; and, the investment productivity (a.k.a return on investment) for each investment was calculated. The following table summarizes this information.

Risk Investment $ (Millions) NPV $ (Millions) Investment Productivity
Unreported Adverse Effects 2 120 55.70
FDA Hold for Adverse Effects 15 335 18.65
Delay in Clinical Trial Enrollment 4 550 128.50
Rewrite FDA Submission 3 88 25.10
  1. If the top three most productive investments were approved for implementation, what would be the total investment and how much enterprise value would be protected as measured in NPV?

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