Answered step by step
Verified Expert Solution
Question
1 Approved Answer
( a ) Sitagliptin is a single enantiomer drug that is prescribed to treat Type 2 diabetes. The chiral centre ( marked with an asterisk
a Sitagliptin is a single enantiomer drug that is prescribed to treat Type diabetes. The chiral centre marked with an asterisk can be introduced during the synthesis by using a transaminase enzyme as shown below. The reaction proceeds by addition of to the face of the ketone functional group of the carbonyl starting material shown.
i Based on this information, establish the absolute configuration of the chiral amine that will form. Show clearly how you reached your answer.
C
Step by Step Solution
There are 3 Steps involved in it
Step: 1
Get Instant Access to Expert-Tailored Solutions
See step-by-step solutions with expert insights and AI powered tools for academic success
Step: 2
Step: 3
Ace Your Homework with AI
Get the answers you need in no time with our AI-driven, step-by-step assistance
Get Started