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A sterile solution for use of are drops was prepared, containing 5mg/ml Compound I as the active ingredient. a. Suggest the likely degradation of this
A sterile solution for use of are drops was prepared, containing 5mg/ml Compound I as the active ingredient. a. Suggest the likely degradation of this compound, if suitable precautions were not taken, and list the factors which might promote this degradation. (3 marks) The eye drops were stored at elevated temperatures and the content of the drug analysed, The first order kinetic rate constants for the degradation are given below: b. i, Use the Arrhenius model o recommend storage conditions which would be suitable for a shelf life of at least three years, based on a lower limit of 90% of the stated amount. (6 marks) ii. Briefly explain why the degradation reaction might be expected to follow first order kinetics. (1 mark)
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