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Aflatoxin Exposure Surface antigen of the hepatitis B virus (HBsAg) Incidence HCC per 100,000 Attributable Risk (AR)/100,000 Rate Ratio (RR) Absent Negative 62.7 Reference 1.00

Aflatoxin Exposure Surface antigen of the hepatitis B virus (HBsAg) Incidence HCC per 100,000 Attributable Risk (AR)/100,000 Rate Ratio (RR) Absent Negative 62.7 Reference 1.00 Positive 118.5 55.8 1.89 Present Negative 96.1 33.4 1.53 Positive 232.4 What is the expected joint RR? A) 1.03 B) 1.18 C) 2.89 D) 3.04. Compare the expected RR and observed RR. Is the multiplicative interaction positive or negative? Note: Assume that there is effect modification in this study without statistical testing, and no random error or bias. A) Negative B) Positive

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