Amrinone is administered by a single IV bolus injection of 75 mg. The plasma concentration-time curve is found to be described by the following equation: Cp = 4.62e-8.94t + 0.64e-0.19t where concentration terms are in units of mg/L, and time terms are expressed in hours.

Calculate a) The apparent volume of the central compartment

b) k12

c) k21

d) The elimination rate constant from the central compartment

e) The elimination half-life of amrinone

f) The clearance of amrinone