An epidemiologist found five cases of big toe cancer in the Yukon Territory. Because there were only a few cases, the epidemiologist decided to conduct a matched case-control study to determine whether shoe size larger than 9 is a risk factor for big toe cancer. Cases were individually matched to one control for daily activity, history of athletes foot, and history of ingrown toenails. The following data were gathered:

Shoe size > 9

Pair Case Control

1 Yes No

2 No No

3 No Yes

4 Yes Yes

5 No Yes

1. Compute the proper measure of association.
2. Interpret your results.
3. If you were to investigate a rare cancer in Lynchburg, where might you look for data?
4. What would be necessary legally and ethically to be able to utilize this data set(s)?