an explantion of The control group received distilled water (D.W)) throughout the entire experimental period as a placebo, the NaF group received NaF by oral gavage (20 mg/kg b.wt.) daily, the protective group (NSO/NaF) was given NSO by oral gavage at a dose of (300 mg/kg b.wt.) two weeks before being given NaF (20 mg/kg b.wt.) and continued until the end of the experiment, whereas the treatment group ((NSO+NaF) was given NSO concurrent with NaF at 300, 20 mg/kg b.wt., respectively