ANOVA & ANCOVA

A study was conducted to demonstrate the effectiveness of an investigational drug product in reducing the number of epileptic seizures in patients who have not been helped by standard therapy. Thirty patients participated in the study, with 15 randomized tothe drug treatment group and 15 to the placebo group. The baseline seizure rates as well as seizure rates for 5 months while on therapy were collected.

Time (months) 1 5 Baseline 2 3 4 Group Patient Drug 15 11 10 5 OHa . WNU 8 Placebo 7 8 6 3 2 3 14 13 11 18 19 20 10 10The GLM Procedure Repeated Measures Analysis of Variance Repeated Measures Level Information Dependent Variable Baseline| Timel| Time2 Time3 Time4 Time5 Level of Time 3 4 5 6 Sphericity Tests Mauchly's Variables DF Criterion Chi-Square Pr > ChiSq Transformed Variates 14 0.0173661 105.78939 <.0001 orthogonal components the glm procedure repeated measures analysis of variance tests hypotheses for between subjects effects source df type iii ss mean square f value pr> F Group 1150.138889 1150.138889 4.58 0.0412 Error 28 7034.022222 251.215079 The GLM Procedure Repeated Measures Analysis of Variance Univariate Tests of Hypotheses for Within Subject Effects Adj Pr > F Source DF Type III SS Mean Square F Value Pr > F G - G H-F-L Time 5 2082.161111 416.432222 39.75 <.0001 time error greenhouse-geisser epsilon huynh-feldt-lecoutre>