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Answer ALL parts a) - c). The following transformation was accomplished using a lipase enzyme in organic solvent. 1 Thermomyces lanuginosus hexane 22 88% yield,

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Answer ALL parts a) - c). The following transformation was accomplished using a lipase enzyme in organic solvent. 1 Thermomyces lanuginosus hexane 22 88% yield, 92% e.e. a) Draw a curly arrow mechanism for the enzyme-catalysed transformation of 1 to 3. You must include the participation of all key active site amino acid residues. [6 b) Why is vinyl acetate (2) used as the acyl donor here, as opposed to the much more inexpensive acetic acid (ethanoic acid, CH3CO2H )? Illustrate your answer with diagram(s). [6 Answer ALL parts a) - c). The following transformation was accomplished using a lipase enzyme in organic solvent. 1 Thermomyces lanuginosus hexane 22 88% yield, 92% e.e. a) Draw a curly arrow mechanism for the enzyme-catalysed transformation of 1 to 3. You must include the participation of all key active site amino acid residues. [6 b) Why is vinyl acetate (2) used as the acyl donor here, as opposed to the much more inexpensive acetic acid (ethanoic acid, CH3CO2H )? Illustrate your answer with diagram(s). [6

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