Answers should directly focus on the questions

4. Briefly explain how a hormone receptor that is an external, peripheral membrane protein can convey a signal to a G-protein that is an internal membrane protein. Ine second step is regulated by thiol (R-SH) groups and manganese ions. The third step is regulated by Pyr?. (a) By analogy with glycolysis, which steps are most likely near equilibrium? (b) Far from equilibrium? (c) Choose ONE step as most likely to be the rate determining step. Use your answers to a) and b), and visual clues in the figure to give TWO fustifications for your choice. (d) Explain the names of the three enzymes catalyzing steps 2-4. 4. Briefly explain how a hormone receptor that is an external, peripheral membrane protein can convey a signal to a G-protein that is an internal membrane protein. Ine second step is regulated by thiol (R-SH) groups and manganese ions. The third step is regulated by Pyr?. (a) By analogy with glycolysis, which steps are most likely near equilibrium? (b) Far from equilibrium? (c) Choose ONE step as most likely to be the rate determining step. Use your answers to a) and b), and visual clues in the figure to give TWO fustifications for your choice. (d) Explain the names of the three enzymes catalyzing steps 2-4