Arthritis is a painful, chronic inflammation of the joints. An experiment on the side effects of pain relievers examined arthritis patients to find the proportion of patients who suffer side effects when using ibuprofen to relieve the pain. The Food and Drug Administration believes more than 3% of users will suffer side effects, if so they will put a stronger warning label on packages of ibuprofen. In a clinical trial 45 out of 1050 patients who used ibuprofen experienced side effects Use a .001 significances level to test the claim.