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As shown below, the amino acid histidine can exist in 4 different protonation states depending on the pH of its environment. a) Which numbered state

As shown below, the amino acid histidine can exist in 4 different protonation states depending on the pH of its environment. a) Which numbered state will histidine exist as at pH 1? pH 11? Neutral pH? b) Which numbered state of histidine could be called a zwitterion?

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HUN pka = 3 pka = 6 H HN HN HEN pka = 10 H2N 3" - *** ** OH HN HN HN HN 1 N 3

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