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b) Bufotenine is found in toad venom. It has potential use in the development of analgesics but it has also been misused as a hallucinegen.

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b) Bufotenine is found in toad venom. It has potential use in the development of analgesics but it has also been misused as a hallucinegen. The pK.H value measured for the most basic group in bufotenine is 9.9 . (i) Predict the site of protonation in the structure of bufotenine that this pK,H value applies to. Ensure that you briefly explain the chemical principles which determine the basicity shown by each amine in the structure [4 marks] (ii) Draw out the equilibrium reaction for the protonation of bufotenine that takes place corresponding to the pK3H value of 9.9

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