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b. Please speculate using SAR arguments in no more than three sentences why the different chemical structures of Compound I and Afatinib may lead to

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b. Please speculate using SAR arguments in no more than three sentences why the different chemical structures of Compound I and Afatinib may lead to different levels of inhibition of the EGFR active site. Your answer should be constructed as if the specifics of the EGFR binding site is not known. (Please refer to chemical structures below) Afatinib

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