Question
calculate the elimination rateconstant and half-life of thedrug. Calculate the volume of distributionof the drug. The AUC of the drug is 41.5 mg hr/L.Calculate the
calculate the elimination rateconstant and half-life of thedrug.
Calculate the volume of distributionof the drug.
The AUC of the drug is 41.5 mg hr/L.Calculate the clearance of the drug
Table 1. Plasma level dataobtained following an I.V. 50 mg bolus dose.
Time, hr | Plasma Concentration, mg/L |
0.25 | 3.0 |
0.50 | 2.8 |
0.75 | 2.3 |
1.0 | 2.2 |
1.5 | 2.0 |
2.0 | 1.8 |
4.0 | 1.4 |
6.0 | 1.2 |
8.0 | 1.1 |
15 | 0.90 |
22 | 0.70 |
30 | 0.55 |
36 | 0.45 |
48 | 0.23 |
60 | 0.15 |
72 | 0.10 |
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