Question
Can you explain this please? Basic drugs (e.g., cinnarizine) has higher absorption with food. On the other hand, absorption of basic drug is reduced when
Can you explain this please? Basic drugs (e.g., cinnarizine) has higher absorption with food. On the other hand, absorption of basic drug is reduced when gastric acid secretion is reduced. I thought a basic drug will be less ionized and thus more absorbed in basic conditions so if gastric acid secretion is reduced, shouldn't it be more absorbed rather than less absorbed?
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Fundamentals of Analytical Chemistry
Authors: Douglas A. Skoog, Donald M. West, F. James Holler, Stanley R. Crouch
9th edition
495558281, 978-0495558286
