Case 3: Opioid Overdose Prevention Rita Shahin is the public health officer for the Toronto District Region. She is attempting to deploy mobile opioid overdose response units across different areas of downtown Toronto. The primary function of these mobile response units is to ensure that opioid users have a safe supply of needles and to minimize overdose deaths the that administration of naloxone (a drug that rapidly reverses the effects of an overdose). Secondary activities include providing supports and referrals for these clients for food, shelter and clothing. Dr. Shahin has 23 mobile response units that she would like to assign to the following six major areas within the Downtown Toronto; Area A - Kensington Chinatown Area B - Entertainment and Financial District Area C - Downtown East Area D - Yonge Dundas Area E - Yorkville and the Annex Area F - Downtown West Each of these 6 major downtown areas require different operating costs per mobile unit deployed due to the varying conditions in each area. Dr. Shahin highest priority requirement is to maintain her daily operating costs to within $4,500 per day. The daily operating costs per downtown area are as follows: Area Description Daily Operating Cost A Kensington/Chinatown $200 B Entertainment and Financial $180 District C Downtown East $220 D Yonge Dundas $240 Yorkville and the Annex $170 F Downtown West $190 Dr. Shahin is interested in reducing the rates of overdose (per 100 injections). She believes that the presence of a mobile unit in a neighborhood will have the effect of reducing the rates of overdose deaths per 100 injections administered as follows. These rates vary by area, and are based on a per single mobile unit deployed into that area. Area Description Overdose Death Reduction (per 100 doses administered) A Kensington/Chinatown 0.27 B Entertainment and Financial 0.24 District C Downtown East 0.28 D Yonge Dundas 0.19 forkville and the Annex 0.23 F Downtown West 0.33Dr. Shahin's second most important goal is to reduce the average overdose death rate for the entire district by at least 5 deaths (per 100 doses administered) If no mobile response units are assigned at all, the average time to respond to a distress call from an overdose anywhere in the district from the main headquarters is 28 minutes. For each mobile response unit that is deployed across any of the areas, the average reduction in response time will change as follows (note that response time improvements vary depending on the specific area): Area Description Reduction in Average Response time per unit deployed (in minutes) A Kensington/Chinatown 0.32 B Entertainment and Financial 0.65 District C Downtown East 0.43 Yonge Dundas 0.87 Yorkville and the Annex 0.55 Downtown West 0.49 Dr. Shahin's third most important objective is to achieve an average response time to overdose distress calls of 15 minutes. Due to the political pressure coming from the various neighborhood areas, Dr. Shahin is required to assign at least two mobile patrol units to each area. In addition, Dr. Shahin believes that no area should have deployed beyond a maximum of 5 mobile response units. Formulate and solve a goal programming model to determine the amount of mobile opioid overdose response units to assign to each area to achieve her goals