Question 5 a) The compound below is a powerful anti-inflammatory drug which inhibits production of prostaglandins. It has a single stereogenic centre. The two enantiomers are shown below. Exp. 1 2 3 4 i) Identify the stereogenic centres in both molecules and assign them as (R) or (S). [2 marks] ii) Explain why only a single enantiomer would be effective at inhibiting prostaglandin production. [N] (mmol dm) 4 [2 marks] b) A pharmacist carried out a kinetics experiment to study the effect of prostaglandin inhibition using this drug, which we shall label as N, together with two cofactors C and D. She obtained the following data: 0.5 0.5 0.5 1.0 [C] (mmol dm-) 0.2 0.4 OH 0.2 0.2 [D] (mmol dm-) 0.2 0.2 0.4 0.2 H Initial rate of inhibition (mmol dm- min) 3.0 x 10-3 6.0 x 10-3 3.0 x 10-3 OH 1.2 x 10- i) Use this data to determine the rate law and the overall order of reaction [5 marks] ii) Determine the value of the rate constant and give the correct units [2 marks] iii) The pharmacist then prepared a solution containing equal concentrations of N, C and D. She found that the initial rate was 0.2025 mmol dm min . Determine the concentration of these solutions. [1 mark]