Consider an SN2 reaction that is catalyzed by an enzyme (such as that on slide 1 where nucleophile is OH - and leaving group is Cl ). Which of the following is likely to be found in the active site. The region of enzyme near the nucleophile has a net positive charge. The region of the enzyme near the nucleophile is neutral. The region of the enzyme near the nucleophile has a net negative charge. The region of the enzyme near the leaving group has a net positive charge. The region of the enzyme near the leaving group is neutral. The regions of the enzyme near the leaving group has a net negative charge. What is the total net charge of the H3PO4H2PO4HPO4PO4 polyprotic system at a pH of 9.6. If necessary, round to the nearest decimal points and include the positive or negative nature of the charge (i.e. +1.2,3.9 ). The Total Net Charge of phosphate at pH9.6 is