Answered step by step
Verified Expert Solution
Link Copied!

Question

1 Approved Answer

Consider two tumor markers for lung cancer, CYFRA 21-1 and CEA, which tend to be elevated in patients with lung cancer relative to those with

Consider two tumor markers for lung cancer, CYFRA 21-1 and CEA, which tend to be elevated in patients with lung cancer relative to those with benign lung disease. A study was conducted on patients with known lung cancer status to assess how these tumor markers could be used for clinical diagnosis. The study team observed that in patients with lung cancer, CYFRA 21-1 is normally distributed with mean 4.7 ng/mL and standard deviation 9.2 ng/mL while CEA is normally distributed with mean 5.9 ng/mL and standard deviation 19.8 ng/mL. In patients with benign lung disease, CYFRA 21-1 is normally distributed with mean 1.6 ng/mL and standard deviation 4.3 ng/mL while CEA is normally distributed with mean 2.2 ng/mL and standard deviation 5.3 ng/mL.

The study team is interested in whether a diagnostic test based on both CYFRA 21-1 and CEA is an improvement over tests based solely on one of the markers. Suppose that a patient is classified as having lung cancer if a patient tests positive for lung cancer if CYFRA 21-1 level is greater than 3.3 ng/mL, or CEA level is greater than 5.0 ng/mL, or both are elevated.

Compute the sensitivity and specificity of this diagnostic test.

Step by Step Solution

There are 3 Steps involved in it

Step: 1

blur-text-image

Get Instant Access to Expert-Tailored Solutions

See step-by-step solutions with expert insights and AI powered tools for academic success

Step: 2

blur-text-image

Step: 3

blur-text-image

Ace Your Homework with AI

Get the answers you need in no time with our AI-driven, step-by-step assistance

Get Started

Recommended Textbook for

Trigonometry

Authors: Cynthia Y Young

5th Edition

1119820928, 9781119820925

More Books

Students also viewed these Mathematics questions

Question

Can every good be a Giffen good? Why or why not?

Answered: 1 week ago

Question

Understand the different approaches to job design. page 167

Answered: 1 week ago