Dashboard Watch Free Full Mo... Sc Hubremoving Login Createx Colours Tra a) [40 Marks] Compounds A and B were found to possess modest activity for a new receptor using SAR by NMR techniques. Eight new derivatives (general structure C) were prepared that linked the two leads via an alkyl bridge However, all of these new compounds possessed lower biological activity than either A or B. (0) Describe SAR by NMR, including any diagrams, and how it is used to develop new drug candidates. (300 words) Why is the biological activity of the new derivatives lower than A and B? Propose new structure(s) (use a bridge length of 4) that might show better activity and explain your reasoning for the choice of your structure. (iii) OH CH A B CH to . C1=1,2,3,4,5,6,7,8 Dashboard Watch Free Full Mo... Sc Hubremoving Login Createx Colours Tra a) [40 Marks] Compounds A and B were found to possess modest activity for a new receptor using SAR by NMR techniques. Eight new derivatives (general structure C) were prepared that linked the two leads via an alkyl bridge However, all of these new compounds possessed lower biological activity than either A or B. (0) Describe SAR by NMR, including any diagrams, and how it is used to develop new drug candidates. (300 words) Why is the biological activity of the new derivatives lower than A and B? Propose new structure(s) (use a bridge length of 4) that might show better activity and explain your reasoning for the choice of your structure. (iii) OH CH A B CH to . C1=1,2,3,4,5,6,7,8