Question
Design an enzyme active site that contains a biomolecule-nucleophile that could attack MIC Methyl isocyanate CH3-N=C=O, and binds well to MIC. Begin by drawing MIC
Design an enzyme active site that contains a biomolecule-nucleophile that could attack MIC Methyl isocyanate CH3-N=C=O, and binds well to MIC. Begin by drawing MIC in the middle, and then build the active site around it. Your drawing should contain: -MIC -An R group that is the nucleophile -Any appropriate R groups or other molecules needed for catalysis of this reaction. Label the catalytic site. -R groups in the binding site. Label the binding site(s). -Draw sufficient R groups that will do non-covalent interactions with the entirety of MIC in the binding site (6-10 total, must not all be the same). -All R groups are appropriately positioned near the parts of MIC they interact with. -Next to every R group provide 1-2 sentences of reasoning stating the R group's function, and why it is appropriate. -Do NOT draw a mechanism. While drawing this, keep in mind what we have learned about enzymes as catalysts and consider: proximity, orientation, limiting movement, and stabilizing the substrate. *You may collaborate with others but I WILL NOT accept any identical answers. If you submit the same answer as a classmate, you will be awarded zero points. You will also be deducted points for exactly repeating any catalytic sites or binding sites or RNAse or serine proteases.
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