Determining the number of Twinkies needed to fill your office would depend on several factors, such as the size of your office and the dimensions of a single Twinkie. To calculate an estimate, you'd need to know the volume of your office space and the volume of a Twinkie Determining the number of Twinkies needed to fill your office would depend on several factors, such as the size of your office and the dimensions of a single Twinkie. To calculate an estimate, you'd need to know the volume of your office space and the volume of a Twinkie