Question
Diazapam (Valium) is a member of the benzodiazepine family of drugs with a pKA value of 3.4. (a) Calculate the % ionized of the basic
Diazapam (Valium) is a member of the benzodiazepine family of drugs with a pKA value of 3.4.
(a) Calculate the % ionized of the basic form of this drug at a pH of 4.35.
(b) What is the LogP value?
(c) Based on the LogP value, is the drug lipophilic or hydrophilic?
(d) Calculate the solubility, Sph, in mg/L at a pH of 4.22 if the S0 is 66mg/L of water.
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Organic Chemistry A Short Course
Authors: Harold Hart, Christopher M. Hadad, Leslie E. Craine, David J. Hart
13th edition
1111425566, 978-1111425562
