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Draw compound 13 in your answer book and circle all the protecting groups (1 mark) What reagent(s) would you choose to selectively remove just the
- Draw compound 13 in your answer book and circle all the protecting groups (1 mark)
- What reagent(s) would you choose to selectively remove just the silyl ethers from 13? (1 mark)
- Using your answers to the parts above, explain what is meant by an orthogonal protecting group strategy. (1 mark)
TBSO OBn OTPS OTBS TPSO- a. n-Buli, THE OBn NNHSO,Ar H 10 b. TBSO TBSO TBSO PS OTPS OBn PS OBn c. LIAIH4. Et0 OBn d. H 11 13 12 TPS = tert-butykdiphenylsilyl (-Si((CeHshC(CH3)s) TBS = tert-butyldimethylsilyl (-Si((CHa),C(CHa)s) Bn = benzyl (CH,Ph) acac = acetylacetonato (CH,COCH,COCH) Buli = butyl lithium (CH;CH;CH2CH,Li) 1.....
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2Reagent for Deprotection of silyl ether Acidic conditions H Fluoride conditions Tetrabutyl amm...
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Business Forecasting With Forecast X
Authors: Holton Wilson, Barry Keating, John Solutions Inc
6th Edition
73373648, 978-9339220426, 9339220420, 978-0073373645
